[Mechanism and diagnostic progress of small cell lung cancer transformation from non-small cell lung cancer after EGFR-TKIs treatment].

This issue of the Chinese Journal of Tuberculosis and Respiratory Medicine published a manuscript on Mechanisms and therapeutic strategies of small cell lung cancer transformation from non-small cell lung cancer after EGFR-TKI treatment. The exploration of relevant mechanisms, diagnosis, and selection of follow-up therapeutic strategies for such patients are practical problems faced by clinician. With the widespread application of targeted therapy with TKIs for non-small cell lung cancer, small cell lung cancer transformation is one of the important resistance mechanisms after TKI treatment. In recent years, the understanding and importance of its pathogenesis, diagnosis, and treatment strategies in clinical practice have been increasing year by year, and new mechanisms for transformation have been explored in depth to further develop precise intervention strategies for patients.