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October 13, 2025

A case report of glycogen storage disease type III combined with Guillain-Barré syndrome and literature review.

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Authors

MYMiaomiao YangXYXinyou YuYZYunyun Zhao

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Overview

Case report identifies motor nerve damage in a child with glycogen storage disease type III and Guillain-Barré syndrome, suggesting critical clinical correlations.

Key Points

  • The child presented with significant motor nerve damage and liver dysfunction linked to glycogen storage disease type III.
  • Genetic testing revealed two compound heterozygous variants in the AGL gene, one classified as likely pathogenic.
  • Electrophysiological examination confirmed severe axonal injury consistent with the acute motor and sensory axonal neuropathy variant of Guillain-Barré syndrome.
  • Despite treatment with intravenous human immunoglobulin, the child's condition deteriorated, leading to multiple organ failures.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68ece2abd1bb2827d1297425https://doi.org/10.3760/cma.j.cn511374-20250115-00034
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Case Report of Glycogen Storage Disorder Type IIIa in a Pediatric Patient: Clinical Approach and Molecular Diagnosis2026
  2. 2A case study of a liver transplant-treated patient with glycogen storage disease type Ia presenting with multiple inflammatory hepatic adenomas: an analysis of clinicopathologic and genetic data2024
  3. 3Clinical features and genetic analysis of 5 cases of infantile-type glycogen storage disease type II: Case reports2024
  4. 4Genotypic and phenotypic features of 39 Chinese patients with glycogen storage diseases type I, <scp>VI</scp>, and <scp>IX</scp>2024 · 3 citations
  5. 5Glycogen Storage Disease Type III: The Critical Role of Cardiac MRI in Detecting Insidious Progression.2025