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October 13, 2025Open Access

Daikenchuto ameliorates dextran sulfate sodium-induced acute and chronic ulcerative colitis by regulating gut microbiota-derived indoles to activate AhR signaling

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Authors

RLRui LiangXLXue LiuQCQinhua Chen

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Overview

Observational analysis finds Daikenchuto modulates gut microbiota and AhR signaling in ulcerative colitis, suggesting new therapeutic avenues.

Key Points

  • Daikenchuto significantly alleviated symptoms of acute and chronic ulcerative colitis.
  • Analysis revealed that gut microbiota composition was altered, enhancing beneficial bacterial species.
  • The study utilized targeted metabolomics to highlight changes in tryptophan metabolism during therapy.
  • Mechanistic studies indicated that AhR signaling participation is crucial for IL-22 secretion and inflammation reduction.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/68ed1896f29694dd1da78de5https://doi.org/10.21203/rs.3.rs-7691083/v1
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