Comparative Study of Efficacy of Itopride versus Levosulpiride Used Orally in Patients Suffering From Non-Ulcer Dyspepsia – Retrospective Study

Background: Dyspepsia is a clinical problem with many manifestations, such as belching, heartburn, anorexia, nausea, and vomiting. Proper medication is necessary; hence, an ideal prokinetic drug has to be studied with a comparison of the efficacy of both drugs. Method: Out of 90 patients with dyspepsia, 45 patients were treated with Itopride and 45 with Levosulpiride, and their efficacy was compared. Results: More relief was observed in the Itopride group 28 (62%) compared to the 22 (48.8%) group of Levosulpiride. Moderate relief was highest in Itopride 15 (33.3%) and 14 (31%); in Levosulpiride, worsening of the symptoms was observed only in Levosulpiride 1 (2.22%). The comparison of serum biochemistry and Q.T interval of both drugs has a significant p-value (p < 0.001). The side effect of diarrhea was 2 (4.4%) in levosulpiride, while headache was 3 (6.6%) in Itopride. Conclusion: Both levosulpiride and Itopride were equally effective and well-tolerated in treating the symptoms of non-ulcer dyspepsia.