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October 15, 2025Open Access

Feeding a low-protein diet exacerbates the susceptibility to Citrobacter rodentium and Dextran Sulfate Sodium-induced intestinal injury in mice.

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Authors

MTMehakpreet ThindUniversity of TorontoMFMary FlanaganHospital for Sick ChildrenSWSanne de WitCross-Cutting Cardiology

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Implication

Observational analysis reveals heightened intestinal injury in malnourished mice with Citrobacter rodentium infection, suggesting compromised barrier function.

Key Points

  • Malnourished mice show increased susceptibility to intestinal inflammation and injury.
  • LPD-fed mice experienced more severe clinical outcomes, increasing the likelihood of reaching humane endpoints.
  • Key markers such as tight junction proteins were reduced in malnourished mice, indicating dysfunction.
  • This study highlights the importance of better preclinical models for studying malnutrition-related enteric dysfunction.

Cite This Study

Thind et al. (2025) studied this question.

synapsesocial.com/papers/68efd921056559ef42877788https://doi.org/10.1101/2025.10.12.681925
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