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October 13, 2025Annals of Internal Medicine

Effectiveness of Recombinant Herpes Zoster Vaccine in the U.S. Medicare Population, 2018 to 2019, by Immunocompetence and Prior Receipt of Live Zoster Vaccine

Nadja A. Vielot Michele Jönsson Funk Til Stürmer‎Jonathan Fix Sylvia Becker‐Dreps David J. Weber Jennifer L. Lund

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Key Points

The recombinant zoster vaccine was found to be effective for immunocompetent individuals, enhancing protection against shingles.
Higher vaccination rates were observed following the preferential recommendation of the recombinant zoster vaccine over the live zoster vaccine.
Observational analysis from Medicare data during 2018 to 2019 revealed significant differences in effectiveness based on prior vaccine receipt and immunocompetence.
This study underscores the importance of vaccine choice, suggesting improved immunity with recombinant options compared to live versions.

Implication

Analysis of recombinant zoster vaccine effectiveness in Medicare beneficiaries shows implications for future vaccination strategies.

Abstract

Recombinant zoster vaccine (RZV) was preferentially recommended over live zoster vaccine (ZVL) starting in 2018.

Discussion

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Cite This Study

Vielot et al. (2025) studied this question.

synapsesocial.com/papers/68f01110f081da0584b56841 https://doi.org/10.7326/annals-24-02409

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