This analysis evaluates the synergistic effects of prebiotics and lactic acid on lactobacillus crispatus growth, highlighting implications for restoring vaginal health.
Background: Bacterial vaginosis (BV) is a common vaginal condition caused by an imbalance in the microbiome. Lactobacillus crispatus plays a key role in vaginal health by producing lactic acid, which lowers pH and inhibits growth of bacteria causing BV. Prebiotic and postbiotic compounds such as D-mannose, glycogen, inulin and lactic acid might help restore a healthy vaginal microenvironment by stimulating growth of L. crispatus.
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Gu et al. (2025) studied this question.
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