Agreements between 24-2 and 24-2C Test Grids for Chloroquine/Hydroxychloroquine Retinopathy Patients and High-Risk Patients

Abstract Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who underwent CQ/HCQ retinopathy screening using the SITA Standard 24-2, SITA Faster 24-2C, optical coherence tomography, fundus autofluorescence, and a dilated eye examination on the same day. Participants were categorized into retinopathy and non-retinopathy groups by graders. The agreement between the two visual field (VF) tests was assessed using Bland-Altman plots. Results Among the 75 participants, 26 (34.67%) were diagnosed with CQ/HCQ retinopathy. Bland-Altman plots show good agreement in median deviation (MD), pattern standard deviation (PSD) and central mean sensitivity (CMS) between tests. The concordance coefficient wasat 0.89-0.93. Significant differences in MD, PSD, and CMS, were observed between the retinopathy and non-retinopathy groups for both VF tests (P<0.048). However, within each group, the results of both VF tests were comparable across all parameters (P=0.08-0.98), except for PSD in the retinopathy group. The SITA Faster 24-2C test had a significantly shorter testing duration. Conclusions The SITA Standard 24-2 and SITA Faster 24-2C tests showed similar efficacy and strongly positive agreement in screening for CQ/HCQ retinopathy. However, the SITA Faster 24-2C minimized the testing time. The addition of testing points within the central 10-degree field did not enhance the detection of CQ/HCQ retinopathy in the Thai population