Beginning with Mandelbrot’s insight that Fisher information may admit a thermodynamic interpretation, a growing body of work has connected this information-theoretic measure to fluctuation–dissipation relations, thermodynamic geometry, and phase transitions. Yet, these connections have largely remained at the level of formal analogies. In this work, we provide what is, to our knowledge, the first explicit realization of the epistemic-to-physical transition of Fisher information within a finite interacting quantum system. Specifically, we analyze a model of N fermions occupying two degenerate levels and coupled by a spin-flip interaction of strength V, treated in the grand canonical ensemble at inverse temperature β. We compute the Fisher information FN(V) associated with the sensitivity of the thermal state to changes in V, and show that it becomes an observer-independent, experimentally meaningful quantity: it encodes fluctuations, tracks entropy variations, and reveals structural transitions induced by interactions. Our findings thus demonstrate that Fisher information, originally conceived as an inferential and epistemic measure, can operate as a bona fide thermodynamic observable in quantum many-body physics, bridging the gap between information-theoretic foundations and measurable physical law.
Plastino et al. (2025) studied this question.