The study demonstrates an electrochemical sensor's ability to detect salicylic acid in real-world samples, suggesting effective monitoring techniques.
Salicylic acid (SA) is a type of contaminant of emerging concern (CEC) belonging to the category of pharmaceutical products. It is a commonly used drug in the treatment of various skin diseases and an over-the-counter (OTC) drug used in an undisciplined manner across the world. It is also used as a supplement for yield improvement in plants. Exposure to high doses of SA can lead to a toxic condition known as salicylism. To better monitor the levels of SA, Ca-doped LaCoO3 (LCCO)/GCE is fabricated in this study. LCCO is synthesized by a solvothermal method and characterised by SEM, FE-TEM, XRD, EDX, and XPS techniques. Substitution of Ca2+ with La3+ results in the formation of oxygen vacancies due to the variation in the oxidation states of Co. The similar ionic radius of La3+ and Ca2+ delivers a better structural stability and better catalytic activity for the perovskite. LCCO/GCE with its excellent catalytic activity could detect SA with a limit of detection (LOD) of 30 nM and a linear range of 0.05-800 μM. The fabricated sensor is reproducible with a relative standard deviation (RSD) of less than 1% and is stable up to 30 days with less than 5% variation from the initial current value. The sensor is also selective in sensing SA, even in the presence of a hundred-fold concentration of other interferents. In addition, the real-world applicability of the sensor is investigated in pond water and acne gels, which both give excellent recovery percentages.
No takes yet. Share an insight, caveat, or question.
Gibi et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: