Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is prevalent among individuals with metabolic risk factors. Accurate, noninvasive quantification of hepatic steatosis is crucial for diagnosis and management. Case Presentation: We report a 52-year-old male (BMI 30.6 kg/m²) with prediabetes and mild dyslipidemia, who underwent lifestyle modification including dietary changes and increased physical activity. Baseline hepatic fat content was assessed using UDFF on the Siemens ACUSON Sequoia system, yielding a mean UDFF of 17%, consistent with moderate hepatic steatosis. After a 6-month intervention period, the patient achieved a BMI reduction to 26.5 kg/m². Follow-up UDFF showed a mean value of 5%, indicating resolution of steatosis. Results: Quantitative analysis demonstrated a substantial reduction in liver fat fraction (from 17% to 5%) accompanied by an improvement in body composition. Conclusion: UDFF effectively monitored changes in hepatic steatosis corresponding with lifestyle-induced weight loss. Its non-invasive nature and accessibility make it a valuable tool for managing MASLD in clinical settings. Keywords: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease (NAFLD), Body Mass Index (BMI), Ultrasound-Derived Fat Fraction (UDFF) 1. Eslam M, Sanyal AJ, George, J.: MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease. Gastroenterology. 2020, 158:1999- 2014. 10.1053/j.gastro.2019.11.312 2. Bozic D, Podrug K, Mikolasevic I, et al.: Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal.Diagnostics (Basel. 2022, 12:2287. 10.3390/diagnostics12102287 3. EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). Journal of hepatology. 2024, 81:492- 542. 10.1016/j.jhep.2024.04.031 4. Labyed Y, & Milkowski A: Novel Method for Ultrasound-Derived Fat Fraction Using an Integrated Phantom. J Ultrasound Med. 2020, 39:2427-2438. 10.1002/jum.15364.
Mukhtar et al. (Wed,) studied this question.