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October 15, 2025Open Access

Supplemental Figure 6 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti–PD-1 Immunotherapy

Leanne G. Ahronian Soumyadip Sahu Minjie Zhang Ayushi S. Patel Ke Geng Reshmee Bhattacharya Gerald S. Falchook Jonathan W. Goldman Alexander I. Spira Salman R. Punekar David R. Spigel Judy S. Wang Ferdinandos Skoulidis Janaye Stephens Mary Meynardie Jaylen M. Powell Alfonso Lopez Michela Ranieri Magdalena A. Ploszaj Yi Jer Tan Yeuan Ting Lee Yi Yu Jiehui Deng Ting Chen Patrick McCarren Alice Tsai Suleman S. Hussain Brian Doyon Kenjie Amemiya Jacques Ermolieff Preksha Shahagadkar Nikitha M. Das Lauren R. Flynn Julie A. Shields Laney Danielczyk Brian J. McMillan Andre Mignault Samuel R. Meier Hsin‐Jung Wu David J. Guerin Douglas A. Whittington Chengyin Min Iga Sienczylo John P. Maxwell Heather DiBenedetto Hideo Watanabe Brian B. Haines Alan Huang Adam Crystal Jannik N. Andersen Xinyuan Wu Kwok‐Kin Wong

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Key Points

TNG260 enhances the effectiveness of anti-PD-1 immunotherapy in STK11-mutant tumors, showcasing treatment synergy.
The small-molecule CoREST inhibitor shows a favorable toxicity profile against hematopoietic lineages in vitro.
This research highlights the potential of combining TNG260 with immunotherapy to improve cancer treatment outcomes.
TNG260 could represent a new approach in sensitizing specific tumor types to immunotherapy, warranting further exploration.

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Implication

TNG260 sensitizes STK11-mutant tumors to anti-PD-1 immunotherapy, indicating potential for improved treatment outcomes.

Abstract

TNG260 has a favorable toxicity profile against hematopoietic lineages in vitro

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Cite This Study

Ahronian et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dccb1 https://doi.org/10.1158/0008-5472.30363289

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplemental Figure 5 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
2Supplemental Figure 9 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
3Supplemental Figure 3 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
4Supplemental Table 6 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
5Supplemental Table 3 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
6Supplemental Table 4 from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
7Data from TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i>-Mutant Tumors to Anti–PD-1 Immunotherapy2025
8TNG260 is a Small-Molecule CoREST Inhibitor that Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy2025 · 9 citations