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October 17, 2025AntioxidantsOpen Access

Androgen-Induced Lactic Acid Accumulation Contributes to the Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome Mice

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Authors

BZBining ZhaoLFLiting FanMLMengfei Liu

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Overview

Experimental analysis shows that lactic acid accumulation leads to apoptosis in granulosa cells, suggesting mechanisms for PCOS.

Key Points

  • Lactic acid accumulation resulting from high androgen levels causes granulosa cell apoptosis in PCOS.
  • Circulating lactic acid was significantly increased in PCOS models, correlating with impaired follicular development.
  • N-Acetylcysteine treatment mitigated mitochondrial damage and reduced lactic acid levels in granulosa cells.
  • Hyperandrogenemia's impact on ovarian morphology highlights potential interventions for managing PCOS symptoms.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcda7https://doi.org/10.3390/antiox14101235
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