This research demonstrates strong antifungal activity in rosemary oil microemulsion against fungal keratitis, indicating its potential for eye drop formulations.
This study investigated the use of Rosmarinus officinalis (rosemary) essential oil in a microemulsion (ME) formulation for the treatment of ocular fungal keratitis, a serious infection that can lead to blindness. The ME was characterized in terms of pH, stability, homogeneity, osmolarity, and other physicochemical properties. The Hen's Egg Test‐Chorioallantoic Membrane assay was used to assess ocular irritancy, and antifungal efficacy was evaluated using the minimum inhibitory concentration method. The oil extraction yielded 1.2%, with eucalyptol (37.89%) as the major compound. The formulation showed a suitable pH (6.96), particle size of 11.35 nm, good stability, and was classified as non‐irritant with an irritation score = 1.5. It exhibited strong antifungal activity against Candida parapsilosis (96.1%), C. krusei (100%), C. albicans (99.1%), Fusarium graminearum (90.5%), and Aspergillus parasiticus (79.5%). The results highlight the potential of rosemary essential oil as a base for developing eye drops for the treatment of fungal keratitis.
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Ribeiro et al. (2025) studied this question.
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