Enantioselective Preparation of (N,O)-, (N,N)- and (N,S)-Spiroketal Moieties

Q: What type of study is this?

This is a Literature Review study.

Mamadou Sow; Edouard Fauran; Laurent Comméiras

doi:10.3390/molecules30204100

October 15, 2025MoleculesOpen Access

Enantioselective Preparation of (N,O)-, (N,N)- and (N,S)-Spiroketal Moieties

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Key Points

This review discusses the preparation of spiroketal moieties using enantioselective methods, enhancing structural diversity in natural products.
Key strategies involve metallo-, organo-, and Lewis acid-catalyzed reactions, showcasing their effectiveness in producing various spiroketal types.
The discussion emphasizes the significance of these spiroketal structures, which are crucial in the design of pharmacologically active compounds.
Novel cycloaddition and annulation reactions are presented, demonstrating their potential in advancing synthetic chemistry applications.

Implication

This review uncovers enantioselective strategies for synthesizing various spiroketal types, highlighting critical catalytic methods.

Abstract

This review highlights enantioselective strategies for preparing (N,O)- (N,N)- and (N,S)-spiroketal skeleton, which are key structural units found in many natural products and pharmacologically active substances. The strategies are mainly based on metallo-, organo- or Lewis acid-catalyzed cycloaddition or annulation reactions.

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Cite This Study

Sow et al. (2025) studied this question.

synapsesocial.com/papers/68f19f1ade32064e504ddb38 https://doi.org/10.3390/molecules30204100

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Enantioselective Preparation of (N,O)-, (N,N)- and (N,S)-Spiroketal Moieties

Key Points

Implication

Abstract

Discussion

Cite This Study

Enantioselective Preparation of (N,O)-, (N,N)- and (N,S)-Spiroketal Moieties

Key Points

Implication

Abstract

Discussion

Cite This Study

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