Review highlights how therapeutic approaches vary despite a common pathogenesis in synovial sarcoma, suggesting unique genetic and epigenetic influences.
Synovial sarcoma is characterized by a typical transcript SS18::SSX. However, despite a common pathogenesis and similar therapeutic approaches, opposite responses to therapy are sometimes observed. Supposedly, this can be associated with additional and alternative pathways of genetic and epigenetic regulation. In this review, the problems of synovial sarcoma diagnosis, pathogenesis and new therapy methods, including targeting epigenetics, are discussed.
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Сенченко et al. (2025) studied this question.
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