Simultaneous Occurrence of Sweet Syndrome and Necrobiosis Lipoidica in Patient with Several Cancers

Acute neutrophilic dermatosis, also known as Sweet syndrome, is a rare disorder that can arise from various etiologies, and in some cases, remains idiopathic. Malignancy-associated Sweet syndrome is uncommon and is often misdiagnosed for years before the correct diagnosis is established. Necrobiosis lipoidica is an inflammatory granulomatous skin disorder often associated with diabetes mellitus, but it may also occur in patients with hypertension, thyroid disease, other inflammatory conditions, or even in otherwise healthy individuals. Rare associations with malignancy have also been described. We report the case of a 64-year-old male presenting with the simultaneous occurrence of Sweet syndrome and Necrobiosis lipoidica on the background of pulmonal and bladder cancer. Infectious, drug-induced, and inflammatory etiologies of the disease were excluded as possible inductors. Routine investigations revealed a pulmonary tumor, alongside a past medical history of low-grade urothelial papillary carcinoma. The presence of multiple neoplasias was considered as the most likely causative factor for the exacerbation of Sweet syndrome.