Abstract FR442: The Association of Nocturnal Blood Pressure Patterns with BMI, Diabetes, and Cardiovascular Dysfunction

Background: Ambulatory Blood Pressure Monitoring (ABPM) offers valuable insights into 24-hour blood pressure (BP) patterns, providing a more comprehensive assessment of cardiovascular risk compared to office-based measurements. This study investigates the relationship between nocturnal BP fluctuations, BMI, diabetes, and cardiovascular dysfunction in a large cohort. Methods: A retrospective analysis of 8199 participants undergoing 24-hour ABPM was conducted. Nocturnal BP patterns were categorized into dipping, non-dipping, reverse-dipping, and extra-dipping. Associations between these patterns and BMI, diabetes, and cardiovascular dysfunction were examined. Additionally, the relationship between menopause status, early-morning hypertension, and diabetes was assessed in female participants. Results: Among participants, 40.7% exhibited hypertension linked to abnormal nocturnal BP patterns (non-dipping 19.16%, 6.22% reverse-dipping, and 1.74% extra-dipping); only 13.06% showed normal dipping pattern. Increased BMI, particularly in overweight and obese categories, was significantly associated with non-dipping and reverse-dipping patterns. These patterns correlated with heightened risks of cardiovascular events, early-morning hypertension, and diabetes. Conclusion: ABPM provides critical insights into abnormal nocturnal BP patterns and their associations with BMI, diabetes, and cardiovascular dysfunction. The findings support broader integration of ABPM into clinical settings to enhance cardiovascular risk assessment and management.