Analysis showcases HGF receptor roles in liver maturation and immune response, highlighting interactions with proteases.
The hepatocyte growth factor (HGF) receptor family - MET and Ron - regulate maturation of the liver in the embryo, as well as having roles in the adult, for example, in the innate immune system. HGF is synthesized as a single gene product, which is post-translationally processed to yield a heterodimer linked by a disulphide bridge. The maturation of HGF is enhanced by a serine protease, HGF activating complex, and inhibited by HGF-inhibitor 1, a serine protease inhibitor. MST1, the ligand of Ron, is two disulphide-linked peptide chains generated by proteolysis of a single gene product.
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Chloe J. Peach (2025) studied this question.
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