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October 18, 2025JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Efficacy of Ceftazidime-avibactam against Multidrug-resistant Gram-negative Pathogens in ICU Patients: A Crosssectional Study from a Subhimalayan Tertiary Care Hospital

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Authors

RSRajender SinghBKBarnali KakatiGMGarima Mittal

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Overview

Cross-sectional study reveals Ceftazidime-Avibactam's limited efficacy against multidrug-resistant pathogens, suggesting careful use.

Key Points

  • Ceftazidime-avibactam showed a sensitivity rate of 37.2% in treating MDR gram-negative pathogens, including Klebsiella pneumoniae and Escherichia coli.
  • Among 94 isolates, limited efficacy against carbapenem-resistant Enterobacterales was observed, with only 21.7% responsiveness.
  • The study highlights the essential need for ongoing antimicrobial surveillance, especially given rising drug resistance in ICU settings.
  • Ceftazidime-avibactam outperformed some second-line antibiotics against ESBL-producing bacteria, but it's crucial to evaluate its use carefully.

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/68f408995de60f8893c6fdc7https://doi.org/10.7860/jcdr/2025/76821.22033
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Addressing the Global Threat of Multidrug-Resistant Infections: The Role of Ceftazidime-Avibactam Revisited2024 · 2 citations
  2. 2In vitro efficacy of ceftazidime/avibactam and cefiderocol against multidrug-resistant Gram-negative uropathogens: insights into β-lactamase-mediated resistance in clinical isolates2026
  3. 3Evaluation of Ceftazidime-Avibactam Susceptibility in Carbapenem-Resistant Gram-Negative Bacteria2025
  4. 4In vitro activity of ceftazidime-avibactam in combination with aztreonam against carbapenem resistant Enterobacterales isolated from intensive care units2024 · 1 citations
  5. 5Antimicrobial susceptibility pattern of newer beta lactam-beta lactamase inhibitor agents on the carbapenem resistant and sensitive strains of Enterobacterales and Pseudomonas aeruginosa2024 · 2 citations