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October 19, 2025Hepatology5 citations

Reclassifying pediatric NAFLD using the steatotic liver disease framework: a multicenter retrospective study from the NASH CRN

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TLTH LamKYKatherine P. YatesSNSheila L. Noon

Key Points

  • Most children diagnosed with NAFLD—about 84%—were reclassified as meeting MASLD criteria based on metabolic risks.
  • The study found that 4.7% of participants met all five cardiometabolic risk factors, revealing potential health concerns.
  • Among participants, 3.2% were reclassified as Met-ALD, indicating alcohol exposure impacts liver disease classification in youth.
  • Finding a systematic diagnostic approach could better account for medication-related liver injury and the effects of alcohol.

Abstract

Background 41 (4.7%) met all five. Thirty-three participants (3.2%) were reclassified as Met-ALD, a prevalence that rose to 5.4% among adolescents. Sixty-six children (6.5%) were reclassified as drug-induced SLD. Conclusions: Most children with NAFLD met MASLD criteria, but nearly 1 in 6 were reclassified based on alcohol use or medication exposure. These findings highlight the need for a systematic diagnostic approach accounting for metabolic risk factors, alcohol use, and medication-related liver injury.

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Cite This Study

Lam et al. (2025) studied this question.

synapsesocial.com/papers/68f43efb854d1061a58ac0e6https://doi.org/10.1097/hep.0000000000001577
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