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October 19, 20251 citationsOpen Access

Development and Validation of an mRNA Vaccine Targeting Mycobacterium tuberculosis

Design and validation of multi-stage expressing mRNA vaccine for Mycobacterium tuberculosis through computational technology

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Authors

MSManika SharmaPBParul BhattMSMedha Singh

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Overview

This study reveals promising mRNA vaccine design for TB, indicating strong immune response and receptor interaction.

Key Points

  • The designed mRNA vaccine shows strong affinity for CD8 and CD4 T cells, enhancing immune response against TB.
  • In-silico analysis confirmed stability of the mRNA construct, ensuring effective translation in host cells.
  • The molecular docking results indicate strong binding of the vaccine to immune receptors TLR2 and TLR4.
  • Immuno-informatics enabled effective design and validation of an mRNA vaccine targeting TB, highlighting its potential.

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/68f43f03854d1061a58ac528https://doi.org/10.21203/rs.3.rs-6579802/v1
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