Abstract Orthopedic implants provide structural support, loading‐bearing, or motion preservation to ensure surgical success. Zinc (Zn)‐based alloys have emerged as promising candidates for next‐generation orthopedic implants due to their suitable degradation rate, excellent mechanical properties, antibacterial activity, and complete degradability. However, the clinical application of Zn‐based alloys is hindered by significant limitations, including mechanical instability, threshold‐dependent bioactivity, an inadequate balance between antimicrobial and osteogenic effects, and variability in stress‐induced degradation. This comprehensive review summarizes the feasibility of Zn‐based alloys for orthopedic implants, focusing on the biocompatibility, biodegradation behavior, mechanical properties, and interactions with the resident cells. The engineering methods to modify properties of Zn‐based materials are also discussed, and their translational applications are highlighted, while addressing the remaining challenges for future investigation. Collectively, advancing research in Zn‐based alloys would pave the way for innovative orthopedic solutions that enhance patient outcomes.
Huang et al. (2025) studied this question.