Biochemical and biophysical markers for prediction of preeclampsia in pregnant nulliparae in Asyut governorate

Background and aim Preeclampsia affects about 5–7% of pregnant women, causing increased morbidity and mortality for the mother and the fetus. The early detection of preeclampsia is still of concern. This study aimed to reassess the value of clinical and biophysical tests, which will be done during routine at 20–34 weeks gestation, for the prediction of gestational hypertension and preeclampsia in pregnant nullipara. Patients and methods This prospective study was recruited at the outpatient clinic of the Obstetrics and Gynecology Department of Al-Azhar University Hospital at Assiut from March 2020 to May 2022. One hundred pregnant women were included in this study. Results The mean patient age is 27 years, mean BMI is 29.2, mean diastolic blood pressure is 108 and mean systolic blood pressure is 155. Total N =87 showing normal liver profile, normal biochemical values in s tyrosine kinase-1, normal values of serum pregnancy-associated plasma protein A, serum placental growth factor, and Doppler indices are normal. Correlation of serum tyrosine kinase with studied parameters showing significantly increased value in serum tyrosine kinase. Conclusion The biochemical markers, soluble Fms-like tyrosine kinase-1 and pregnancy-associated plasma protein A, and the biophysical markers, Uterine Artery Pulsatility Index and Uterine Artery Resistance Index were good markers for the prediction of preeclampsia in nullipara pregnant women.