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October 20, 2025Open Access

Dietary bioactives increase gut microbiome diversity and alter host and microbial metabolite profiles

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Authors

ADAnthony DuncanFBFederico BernuzziJAJennifer Ahn‐Jarvis

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Overview

Randomised crossover trial reveals increased gut microbiome diversity and altered metabolite profiles with high bioactive diet, suggesting potential health benefits.

Key Points

  • High intake of dietary bioactives significantly increased alpha diversity of microbial taxa and function.
  • Metabolite profiles were more strongly associated with dietary intervention than microbiome profiles, indicating active community changes.
  • In a randomised crossover intervention trial, twenty healthy subjects followed high and low bioactive diets over a four-week period.
  • Results emphasize the need for future studies to focus on metabolic activities rather than just microbial composition.

Cite This Study

Duncan et al. (2025) studied this question.

synapsesocial.com/papers/68f5a78aab63786de5b46021https://doi.org/10.1101/2025.10.16.25338140
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