Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 20, 2025TransfusionOpen Access

How do I overcome apheresis collection challenges for sickle cell disease gene therapy

View Full Paper
Ask AI
Bookmark
Share

Authors

YTYvette C. TanhehcoNewYork–Presbyterian HospitalGGGaurav K. GuptaMemorial Sloan Kettering Cancer CenterNSNirupama SinghUniversity of Alabama at Birmingham

Discussion

Loading...

Member takes

Overview

Working group identifies apheresis collection challenges and strategies for gene therapy in sickle cell disease.

Key Points

  • Apheresis collection challenges must be addressed to optimize gene therapy for sickle cell disease.
  • Patients often require multiple cycles of red blood cell exchange and stem cell collection, complicating treatment.
  • Effective mobilization of hematopoietic stem cells is critical to ensure sufficient material for gene therapy.
  • Coordinated efforts among all stakeholders enhance personalized treatment plans for successful outcomes.

Cite This Study

Tanhehco et al. (2025) studied this question.

synapsesocial.com/papers/68f5fcce8d54a28a75cf1cachttps://doi.org/10.1111/trf.18461
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Highly efficient collection and manufacture of autologous HSC gene therapy cell product for patients with sickle cell disease using a lentiviral vector containing a shmir targeting BCL11a2025 · 1 citations
  2. 2Gene therapy for sickle cell disease: Practice recommendations from the American Society for Transplantation and Cellular Therapy and the International Society for Cell & Gene Therapy2026 · 5 citations
  3. 3Current state of gene therapy in sickle cell disease2024 · 14 citations
  4. 4The New Era of Curative Therapies for Sickle Cell Disease: A Comprehensive Review of Allogeneic Transplantation and Autologous Gene Therapy2026
  5. 5The Journey of Gene Therapy in Sickle Cell Disease: How Molecular Advances Meet Clinical Care2026