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October 21, 2025International Journal of Molecular SciencesOpen Access

Benzodimidazole–Naphthalen-Arylmethanone Regioisomers as CB1 Ligands: Evaluation of Agonism via an Indirect Cytotoxicity-Based Approach

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Authors

ACAnalia Young Hwa ChoRRRenato Burgos RavanalVSVerónica Salazar

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Overview

Assessment reveals novel compounds exhibit CB1 receptor binding affinity and induce apoptosis in glioma cells, suggesting potential as therapeutic agents.

Key Points

  • Compounds 4d, 5b, 5e, and 5f' showed significant toxicity against U87MG malignant glioma cells.
  • Compound 5f' demonstrated a strong CB1 affinity with a Ki value of 2.12 µM, highlighting its potential as a therapeutic agent.
  • Indirect cytotoxicity assessment indicated effective modulation of glioma cell proliferation via CB1 receptor agonism.
  • Findings support the structural importance of the furan ring for developing new ligands targeting CB1 agonist activity.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/68f74e597f21f73e19e5b5b8https://doi.org/10.3390/ijms26209986
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