Combined Sodium Aescinate And Calf Blood Extract Gel For Corneal Foreign Body Injury

The aim of this study was to assess the efficacy of combining sodium aescinate tablets with deproteinized calf blood extract eye gel (DCB-EG) in treating corneal foreign body injuries. This retrospective study included 270 patients divided into three groups: Combination (sodium aescinate + DCB-EG, n=90), Gel (DCB-EG, n=90) and Control (routine anti-infection, n=90). Primary outcome was clinical efficacy rate; secondary outcomes included pain scores (VAS), corneal healing metrics, inflammatory markers (IFN-?, TNF-?, IL-17), tear film stability (BUT), corneal epithelial status (CESS), tear secretion (SIt) and ocular surface disease index (OSDI). Data were analyzed using ANOVA or Chi-square test. The research results showed that the Combination group achieved the highest efficacy (98.89%), significantly better than the Gel (91.11%) and Control (86.67%) groups (P<0.05). Combined intervention shortened corneal edema resolution time, corneal healing time and pain relief time, while also reducing VAS scores and inflammatory factor levels (all P<0.05). Additionally, the Combination group demonstrated superior tear film stability, corneal epithelial repair and subjective symptom improvement compared to the Control group (all P<0.05). No significant differences in adverse events were observed (P>0.05). The combination therapy provided a safe and optimized treatment method for corneal foreign body injuries.