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October 23, 2025Journal of DiabetesOpen Access

Effects of Intensive Systolic Blood Pressure Control on Kidney Outcomes in Patients With and Without CKD: A Post Hoc Analysis of SPRINT and ACCORD‐BP Trials

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Authors

XXXiaoli XuXZXuan ZhaoYDYi Ding

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Overview

Post hoc analysis reveals intensive blood pressure control reduces renal failure risk in chronic kidney disease, suggesting increased risk for mild CKD progression.

Key Points

  • Intensive systolic blood pressure control reduced renal failure risk in chronic kidney disease participants, and increased mild progression risk.
  • Total participants numbered 10,946, with 2,724 classified as chronic kidney disease cases under analysis.
  • Cox proportional hazards models assessed risk differences in kidney outcomes between intensive and standard blood pressure control.
  • Results may impact treatment strategies in managing hypertensive patients with chronic kidney disease.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68f9840c1881b68f3b7ae77ehttps://doi.org/10.1111/1753-0407.70162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of intensive blood pressure control on cardio-kidney outcomes by KDIGO risk categories: a Post Hoc analysis of ACCORD-BP and SPRINT trials2026
  2. 2Effect of Intensive Blood Pressure Control on Kidney Outcomes2023 · 16 citations
  3. 3Estimated glomerular filtration rate and the risk–benefit profile of intensive blood pressure control amongst nondiabetic patients: a post hoc analysis of a randomized clinical trial2017 · 64 citations
  4. 4Effects of Intensive Systolic Blood Pressure Lowering on End-Stage Kidney Disease and Kidney Function Decline in Adults With Type 2 Diabetes Mellitus and Cardiovascular Risk Factors: A Post Hoc Analysis of ACCORD-BP and SPRINT2023 · 10 citations
  5. 5Effects of Intensive BP Control in CKD2017 · 476 citations