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October 23, 2025The Journal of Organic Chemistry

Controllable Phosphorothiotrifluoromethylation and Hydrotrifluoromethylation of Unactivated Alkenes in Water

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Authors

CGChi GaoHZHongye ZhuCXCong Xu

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Overview

Research shows redox reaction enables efficient hydrotrifluoromethylation in alkenes, suggesting a greener synthetic route.

Key Points

  • Hydrotrifluoromethylation offers an efficient approach for alkene modification.
  • Key benefits include operational simplicity and environmental sustainability in synthesis.
  • The redox strategy is applied in metal-free conditions, enhancing the process's accessibility.
  • Findings highlight potential for late-stage functionalization in organic chemistry.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68f9d6583f378872224925bahttps://doi.org/10.1021/acs.joc.5c02012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Accommodating Styrenes and Unactivated Olefins: Hydrotrifluoromethylation Using O,O′-Dimethyldithiophosphoric Acid as SET Reductant and H Atom Donor2025 · 2 citations
  2. 2Copper and Photocatalytic Radical Relay Enabling Fluoroalkylphosphorothiolation of Alkenes: Modular Synthesis of Fluorine-Containing S -Alkyl Phosphorothioates and Phosphorodithioates2021 · 57 citations
  3. 3Evolution and Future of Hetero‐ and Hydro‐Trifluoromethylations of Unsaturated C−C Bonds2023 · 57 citations
  4. 4The dual role of thiourea in the thiotrifluoromethylation of alkenes2016 · 46 citations
  5. 5Visible-light-promoted photocatalyst- and additive-free intermolecular trifluoromethyl-thio(seleno)cyanation of alkenes2020 · 62 citations