Substrate Structure Modulates the Catalytic Dynamics of HDAC8 at the Single-Molecule Level

Q: What type of study is this?

This is a Experimental Study study.

Seungyong You; Sakurako Tani; Sanku Mallik; Zhongyu Yang; Mohiuddin Quadir; Yongki Choi

doi:10.1039/d5cy00729a

January 1, 2025Catalysis Science & TechnologyOpen Access

Substrate Structure Modulates the Catalytic Dynamics of HDAC8 at the Single-Molecule Level

View Full Paper

Ask AI

Bookmark

Share

Key Points

Catalytic dynamics of HDAC8 are modulated by substrate structure, enhancing enzyme activity.
Substitutions on HDAC8 substrates significantly alter the enzyme's conformational landscape.
Observational analysis using single-molecule electronic sensors captures enzyme behavior at a granular level.
Findings highlight the importance of substrate structure in designing effective catalysts.

Implication

Single-molecule analysis reveals how substrate modifications affect HDAC8 dynamics, suggesting implications for catalyst design.

Abstract

Understanding how substrate structure alters an enzyme's conformational landscape is central to catalyst design. Using single-molecule electronic sensors, we reveal how substitutions on an HDAC8 substrate modulate the enzyme's underlying...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

You et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3d40 https://doi.org/10.1039/d5cy00729a

View Full Paper

Ask AI

Bookmark

Share

Substrate Structure Modulates the Catalytic Dynamics of HDAC8 at the Single-Molecule Level

Key Points

Implication

Abstract

Discussion

Cite This Study

Substrate Structure Modulates the Catalytic Dynamics of HDAC8 at the Single-Molecule Level

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading