Organophotocatalytic synthesis improves yields in allylic difluorides, suggesting greener alternatives in chemical processes.
An organophotocatalytic process for the defluorinative -substitution of allylic difluorides with N-alkylanilines, 2-oxoacids and N-protected -amino acids was devised, which was previously reported using metal-based photoredox catalysts. In several instances, the organophotocatalytic reaction conditions produced comparable or better yields than the metal-based catalytic process. Additionally, our new method has expanded the functional group tolerance to include N-acetyl -amino acids. Fine-tuning each set of reaction conditions to implement organophotocatalysis provided a greener and more affordable avenue towards the synthesis of monofluoroalkenes.
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Semeniuk et al. (2025) studied this question.
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