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October 23, 2025Cell Communication and SignalingOpen Access

Phenotype switching in highly invasive resistant to vemurafenib and cobimetinib melanoma cells

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Authors

ASAleksandra SimiczyjewMKMagdalena KotMMMichał Majkowski

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Overview

Analysis reveals enhanced cell migration and invadopodia formation in melanoma cells resistant to BRAF and MEK inhibitors, suggesting new therapeutic targets.

Key Points

  • Resistant melanoma cells demonstrate significantly increased invasion and migration compared to sensitive controls.
  • Protease activity and focal adhesion kinase are elevated in double-resistant melanoma cells, indicating aggressive behavior.
  • Focal adhesion kinase activation and invadopodia formation contribute to enhanced cell mobility and invasiveness.
  • Targeting this invasive phenotype of melanoma may improve clinical outcomes for patients given current drug limitations.

Cite This Study

Simiczyjew et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f7420d8https://doi.org/10.1186/s12964-025-02452-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib)2024 · 1 citations
  2. 2Comparative Proteomic Analysis of the Secretome of Control and BRAF/MEK Inhibitor-Resistant Melanoma Cells2026
  3. 3Comprehensive transcriptomic characterization of two melanoma cell lines with acquired dual resistance to BRAF and MEK inhibitors2026 · 2 citations
  4. 4Abstract 5869: Investigation of molecular alterations associated with double resistance to BRAF and MEK inhibition in melanoma2024
  5. 5Molecular Basis of BRAF Inhibitor Resistance in Melanoma: A Systematic Review2025 · 18 citations