⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 24, 2025Open Access

Activation of Human CD8+ T Cells Results in a Highly Selective and Very Potent Upregulation of Interferon-r, TNF-a, IL-2 and Granzyme B, But Not of Other Granzymes and Perforin

Srinivas Akula Animamalar Mayavannan Sara Wernersson Jenny Hallgren Lars Hellman

View Full Paper

Ask AI

Bookmark

Share

Key Points

Granzyme B expression increased by 30-40 fold within 4 hours of activation, highlighting its importance in apoptosis.
A remarkable 1000-fold increase in Interferon-γ was noted, indicating strong proinflammatory response upon CD8+ T cell activation.
Transcriptomic analysis revealed significant changes in a selective number of cytokines, mainly IL-2 and chemokines, after stimulation.
Findings imply that while Granzymes are crucial, cytotoxic T cells can also induce potent inflammatory responses.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Activation increases granzyme B and proinflammatory cytokines in cytotoxic T cells, suggesting apoptosis plays a pivotal role.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Akula et al. (2025) studied this question.

synapsesocial.com/papers/68ff87e9c8c50a61f2bdd20d https://doi.org/10.20944/preprints202510.1922.v1

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell–Mediated Cytotoxicity2024 · 7 citations
2Defining the Differentiation Mechanisms of Pathogenic Granzyme K+ CD8 T cells 39372025
3Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus‐specific CD8+ T cellsOriginal Research · 2015 · 17 citations
4Gzmk+ CD8 T cells in inflammatory diseases2025 · 11 citations
5Antigen-specific regulatory T cells eliminate cognate CD4 effector T cells through perforin, granzyme B, and BimOriginal Research · 2026

More related papers

Association of CD8+TILs co-expressing granzyme A and interferon-γ with colon cancer cells in the tumor microenvironment2024
On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes2026
Abstract 5404: Tumor cell targeted granzyme B demonstrates direct cytotoxic action and indirect immunogenic cell death mediated through numerous defined proteins.2026