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Review highlights preclinical evaluation of advanced biomaterials using porcine corneal models, suggesting their role in clinical applications.
The development of advanced biomaterials for corneal applications requires robust trans-lational platforms that faithfully replicate human characteristics. Porcine corneas are in-creasingly recognized for ophthalmic research. Their unique combination of anatomical similarity, biomechanical comparability, and accessibility make them highly suitable for preclinical evaluation of innovative therapies, bridging the gap between preclinical dis-covery and clinical application. This review outlines the utility of porcine corneal models in validating advanced biomaterials, particularly in ex vivo settings, focusing on current methodologies, while addressing challenges and future directions. We aim to underscore the potential of porcine corneal models to accelerate the translation of next-generation biomaterials into clinically relevant corneal therapies.
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Nápoles et al. (2025) studied this question.
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