Clinical Value of Glibenclamide Combined with Metformin in the Treatment of Diabetes Mellitus in the Elderly

This study investigated the clinical efficacy of glimepiride combined with metformin in elderly diabetic patients. A total of 120 elderly diabetic patients admitted to our hospital between March 2023 and June 2025 were enrolled. Using a randomized block design, the patients were divided into two groups for prospective analysis. The control group received metformin monotherapy, while the observation group received glimepiride combined with metformin. Comparative analyses demonstrated that both groups showed lower fasting blood glucose levels (P<0.05) and lower 2-hour postprandial glucose levels (P>0.05). The combined treatment also showed significantly better glycemic control than metformin monotherapy, with no increased risk of adverse reactions observed. The study concluded that glimepiride combined with metformin effectively managed blood glucose levels in elderly diabetic patients without increasing adverse effects.