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November 4, 2025Sciences of PhytochemistryOpen Access

Antimalarial Activity of Globimetula oreophila Compounds: In Silico Docking Investigations on Plasmodium falciparum Protease

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Authors

DGDauda GarbaBABila Hassan AliBBBashar Bawa

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Overview

In silico docking revealed potent inhibition of Plasmodium falciparum proteases by Globimetula compounds, indicating new antimalarial therapy potential.

Key Points

  • Compounds from Globimetula oreophila show significant antimalarial activity against Plasmodium falciparum proteases.
  • Dihydrostilbene exhibited the highest binding affinity of -10.3 kcal/mol to PfDHFR, compared to cycloguanil's -10.7 kcal/mol.
  • Docking analysis utilized binding affinities, highlighting interactions via hydrogen bonds and van der Waals forces.
  • These findings support exploration of natural products in developing novel antimalarial drugs, specifically targeting key proteases.

Cite This Study

Garba et al. (2025) studied this question.

synapsesocial.com/papers/690945348f2297dc13532f74https://doi.org/10.58920/sciphy0402314
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Also Consider

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  1. 1Virtual Screening of Natural Products and Drugs as Inhibitors against Aspartate Transcarbamoylase and Orotidine-5'-Monophosphate Decarboxylase in Plasmodium falciparum2019
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  4. 4Deciphering the inhibitory activity of flavonoids against Plasmodium falciparum proteases through molecular docking, drug-likeness and pharmacokinetic studies2025 · 1 citations
  5. 5Structure-Based Screening of Deep-Sea Microbial Metabolites Against Plasmodium falciparum Dihydroorotate Dehydrogenase2026