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Demonstrates elevated plasma atherogenic and triglyceride-glucose indices in transfusion-dependent thalassemia, indicating non-linear cardiovascular risk tied to severe iron burden.
TDT patients show significant hematological and metabolic deviations, including elevated cardiovascular risk markers like PAI and TyG index. As iron burden increases, these markers lose discriminative power, and cardiac involvement escalates rapidly once a critical iron threshold is surpassed, as supported by studies showing a non-linear relationship between iron load and cardiac complications. Comprehensive cardiovascular risk assessment and tailored management are essential for these patients. Future studies should focus on tracking cardiovascular risk progression and the effects of targeted interventions.
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Yalçın et al. (2024) studied this question.
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