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Observational analysis shows intact endogenous pain inhibition in chronic complex regional pain syndrome type 1, indicating increased pain facilitation mechanisms.
Our results indicate that in individuals with chronic CRPS type 1, endogenous pain inhibition is intact and comparable with healthy individuals. Therefore, pathomechanisms underlying chronic CRPS are likely related to increased pain facilitatory rather than impaired inhibitory processes.
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Allmendinger et al. (2025) studied this question.
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