Findings reveal parathyroid hormone-related protein affects chondrocyte development in growth cartilage, indicating its essential role in proliferation and matrix production.
Loss of the PTHrP (67 -139) domain causes impaired proliferation, reduced matrix production, and increased extracellular matrix degradation in epiphyseal chondrocytes. These findings demonstrate that PTHrP (67 -139) is required to maintain chondrocytes in an immature state and that its absence leads to premature differentiation of epiphyseal growth plate chondrocytes.
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Hashmi et al. (2025) studied this question.
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