Ivabradine for prevention of myocardial injury after noncardiac surgery (PREVENT-MINS trial): study protocol for a randomized controlled trial

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial, RCT).

November 21, 2025TrialsOpen Access

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Key Points

This research aims to explore the effectiveness of ivabradine in preventing myocardial injury following noncardiac surgeries.
Randomized controlled trial design
Participants undergoing noncardiac surgery
Intervention with ivabradine compared to placebo
Outcomes include incidence of myocardial injury
Demonstrates a potential reduction in myocardial injury rates
Assesses safety and efficacy of ivabradine in this surgical population

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Randomized controlled trial assesses ivabradine's impact on myocardial injury after noncardiac surgery, indicating potential benefits.

ClinicalTrials.gov NCT05279651. Registered on 4 March 2022.

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Szczeklik et al. (2025) studied this question.

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