Predictive modeling identifies binding affinity of pimodivir combinations in influenza A, suggesting effective combination therapies.
This study introduces a machine learning framework to predict effective antiviral combinations for influenza A. It identifies Pimodivir with Epinephrine or L-Adrenaline as synergistic agents, confirmed by experiments demonstrating increased binding affinity and viral suppression. Multiple synergy scoring methods validate these drug combinations' potential, offering a strategic pathway for designing rational combination therapies against influenza and other RNA viruses.
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Luo et al. (2025) studied this question.
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