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November 21, 2025Scientific ReportsOpen Access

Multimorbidity, disease clusters and risk of all-cause and cause-specific mortality: a population-based prospective cohort study

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Authors

TLThomas J LittlejohnsWLWenyu LiuCCCatherine M. Calvin

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Overview

Prospective cohort study shows multimorbidity increases mortality risk in adults, implying healthcare strategies should address disease clusters.

Key Points

  • This research investigates the effects of multimorbidity on mortality risk in a large population cohort.
  • Population-based cohort study involving 502,370 UK Biobank participants aged 40-70
  • Participants reported health conditions in nurse-led interviews
  • Cox proportional-hazards regression models used to analyze mortality data
  • Follow-up period averaged 13 years with 44,399 deaths recorded
  • Observations indicated dose–response relationships between multimorbidity and all-cause mortality
  • Age-specific disease clusters revealed significant associations with mortality risk
  • Particular clusters of conditions linked to higher mortality in both men and women

Cite This Study

Littlejohns et al. (2025) studied this question.

synapsesocial.com/papers/6924e3f2c0ce034ddc34f10chttps://doi.org/10.1038/s41598-025-25285-w
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