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Findings reveal zinc binds to STIM1, enhancing calcium signaling, suggesting zinc influences ER calcium balance.
Our results identify a zinc-binding module upstream of the EF-hand as a critical determinant of STIM1 activation. These findings provide new insights into the molecular interplay between zinc and calcium signaling and suggest a regulatory mechanism by which cellular zinc levels may influence ER calcium homeostasis.
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Alary et al. (2025) studied this question.
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