PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
November 21, 2025eLifeOpen Access

Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction

View Full Paper
Ask AI
Bookmark
Share

Authors

YCYen-Ching ChangYPYi Jheng PengJLJoo Yeun Lee

Discussion

Loading...

Member takes

Overview

Research reveals neurons and glial cells regulate synaptic remodeling via molecular mechanisms in Drosophila NMJ.

Key Points

  • This research aims to understand the collaborative role of neurons and glial cells in synaptic remodeling.
  • Utilized Drosophila neuromuscular junction as a model system.
  • Investigated the role of peripheral glial cells and neurons in synaptic plasticity.
  • Analyzed the effect of the protein shriveled (Shv) on synaptic remodeling.
  • Glial cells collaborate with neurons to control synaptic remodeling.
  • Glial Shv is necessary for synaptic plasticity but does not activate integrin signaling.
  • Loss of glial cells results in similar phenotypes to loss of Shv.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/6924e405c0ce034ddc34f7efhttps://doi.org/10.7554/elife.104126.3
View Full Paper
Ask AI
Bookmark
Share