Observational study shows postoperative complications could rise with anti-rheumatic drug discontinuation in rheumatoid arthritis, indicating safety issues in orthopedic surgery.
In orthopedic surgery for patients with RA, maintaining the standard or the half of administration interval of bDMARD appears safe in the preoperative period. However, the drug discontinuation may increase the risk of postoperative flare-ups, particularly with IL-6 inhibitors. In addition, T-cell function modifiers may be associated with a lower risk of delayed wound healing, suggesting their safety profile in this context.
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Ito et al. (2025) studied this question.
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