Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis

Yishan Bian; Qilan Wang; Qixing Liang; Yuzhe Zhu; Chengliang Wu; HongFeng RUAN; Xueqin Hu

doi:10.1016/j.intimp.2025.115820

November 20, 2025International ImmunopharmacologyOpen Access

Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis

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Key Points

This research explores how catalpol can mitigate postmenopausal osteoporosis and its mechanisms.
In vivo study using OVX mice to model estrogen deficiency.
Assessment of SIRT1 activity in osteoblasts.
Measurement of P53 deacetylation and CASPASE-3 activity.
Catalpol administration significantly reduced bone loss in OVX mice.
SIRT1 activation was confirmed to inhibit CASPASE-3-driven apoptosis in osteoblasts.
P53 deacetylation was increased with catalpol treatment, indicating SIRT1 involvement.

Implication

Findings reveal catalpol reduces bone loss in postmenopausal osteoporosis, impacting osteoblast apoptosis via SIRT1.

Abstract

These findings support a SIRT1-centered mechanism whereby CAT engages SIRT1 in cells to restrain the P53-CASPASE-3 apoptotic program in osteoblasts and mitigate estrogen-deficiency bone loss in OVX mice.

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Cite This Study

Bian et al. (2025) studied this question.

synapsesocial.com/papers/6924e405c0ce034ddc34f8f5 https://doi.org/10.1016/j.intimp.2025.115820

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Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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