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This research aims to evaluate trends in mortality related to extreme prematurity in neonates across demographic groups.

November 20, 2025Frontiers in PediatricsOpen Access

Mortality trends in extremely premature neonates: insights from the CDC WONDER database from 1999 to 2023

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This research aims to evaluate trends in mortality related to extreme prematurity in neonates across demographic groups.
Utilized the CDC WONDER database for data on infant mortality from 1999 to 2023.
Employed Joinpoint regression for analysis of crude mortality rate, annual percent change, and average annual percent change.
Stratified data by sex, race, region, and urban vs. rural locality.
Extreme immaturity resulted in 92,917 deaths among neonates in their first year of life from 1999 to 2023.
Overall crude mortality rate significantly decreased across the study period.
Significant decreases in mortality were observed for Black or African American and White neonates.
Urban localities saw a decrease in mortality, while rural localities did not.

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Analysis shows declining mortality in extremely premature neonates, indicating disparities among demographic groups.

Hammond et al. (2025) studied this question.

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