Clinical study reports enhanced differentiation of DPSCs with xylitol, suggesting a role as a bioactive agent.
A BSTRACT Purpose: This study evaluates the impact of xylitol on the differentiation of dental pulp stem cells (DPSCs) in clinical settings, focusing on its potential as a bioactive agent to enhance regenerative outcomes. Methods: A controlled clinical study involving 40 patients assessed DPSCs isolated from extracted third molars. Patients were divided into two groups: xylitol-treated (Group A) and control (Group B). Differentiation was evaluated over 14 days using alkaline phosphatase (ALP) activity assays, immunohistochemistry, and mineralization analysis. Results: Xylitol treatment significantly enhanced odontogenic differentiation, evidenced by increased ALP activity (Group A: 78.6 ± 5.4 U/mg; Group B: 56.3 ± 4.7 U/mg, P < 0.05) and higher expression of odontogenic markers. Mineralization was markedly superior in the xylitol group ( P < 0.05). Conclusion: Xylitol promotes DPSC differentiation, making it a promising adjunct for dental regenerative therapies. Further research into its molecular mechanisms is warranted.
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Albariqi et al. (2025) studied this question.
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