Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1/Nrf2/NF-κB pathway

This study demonstrated that in the R28 cell injury model induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation, SCU can promote the proliferation of R28 cells and reduce the expression of apoptotic factors through the antioxidant stress effect mediated by the Keap1/Nrf2/Nf-κB signaling pathway. This finding provides a potentially effective candidate compound and a mechanistic approach for the drug treatment of glaucoma optic nerve protection.